Elucidating the selectivity of dyotropic rearrangements of β-lactones: a computational survey

文献信息

发布日期 2021-11-25

DOI 10.1039/D1QO01591E

影响因子 5.281

作者

Jingyang Zhang, Yumiao Ma, Ke Qiu, Bo Li, Zhengwen Xue, Boxue Tian, Yefeng Tang

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摘要

The dyotropic rearrangement of β-lactones is a neglected treasure in the family of multi-bond reactions and pericyclic reactions. Despite its appealing synthetic potential, the complicated migration selectivity greatly limits its widespread application. In this work, we report the first systematic and comprehensive computational study on the dyotropic rearrangements of β-lactones. The use of the double-hybrid functional ensures the accuracy of results. On the basis of the present study and our previous work, five methods to control the reaction selectivity of dyotropic rearrangements of β-lactones have been summarized, providing valuable references for synthetic chemists to design and develop brand-new type dyotropic reactions.

期刊推荐

Main Group Chemistry

Bioorganic & Medicinal Chemistry Letters

Cellulose

Colloid Journal

Acta Metallurgica Sinica-English Letters

Bioorganic & Medicinal Chemistry

Journal of Chemical Sciences

Medicinal Chemistry Research

Journal of Asian Natural Products Research

Critical Reviews in Solid State and Materials Sciences

来源期刊

Organic Chemistry Frontiers

CiteScore: 7.8

自引率: 8.7%

年发文量: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Elucidating the selectivity of dyotropic rearrangements of β-lactones: a computational survey

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来源期刊

Organic Chemistry Frontiers

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