Water-promoted regio-selective trifluoromethylation of vinyl conjugated diazoacetates
文献信息
发布日期
2021-12-01
DOI
10.1039/D1QO01654G
影响因子
5.281
作者
Xinxin Han, Xin Liu, Yueyun Bao, Hunahuan Song, Yu-Rou Zhao, Xiaoying Wang, Junjie Zhang, Le Liu, Xin-Hua Duan, Jinbo Hu, Mingyou Hu
查看原文
摘要
An efficient trifluoromethylation reaction of vinyldiazoacetates under mild reaction conditions was depicted. Pre-generated CuCF3 was used as a trifluoromethylation reagent and water acted as both a promoter and proton source. The reaction is compatible with a broad scope of functional groups and easy to scale-up. The wide functional group tolerance of the reaction enables further synthetic manipulation of the products.
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来源期刊
Organic Chemistry Frontiers
CiteScore:
7.8
自引率:
8.7%
年发文量:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
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