Water-promoted regio-selective trifluoromethylation of vinyl conjugated diazoacetates

文献信息

发布日期 2021-12-01

DOI 10.1039/D1QO01654G

影响因子 5.281

作者

Xinxin Han, Xin Liu, Yueyun Bao, Hunahuan Song, Yu-Rou Zhao, Xiaoying Wang, Junjie Zhang, Le Liu, Xin-Hua Duan, Jinbo Hu, Mingyou Hu

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摘要

An efficient trifluoromethylation reaction of vinyldiazoacetates under mild reaction conditions was depicted. Pre-generated CuCF3 was used as a trifluoromethylation reagent and water acted as both a promoter and proton source. The reaction is compatible with a broad scope of functional groups and easy to scale-up. The wide functional group tolerance of the reaction enables further synthetic manipulation of the products.

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Atomization and Sprays

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Herald of the Russian Academy of Sciences

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Bioorganic & Medicinal Chemistry

Critical Reviews in Solid State and Materials Sciences

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Chinese Journal of Chemistry

Biocatalysis and Biotransformation

来源期刊

Organic Chemistry Frontiers

CiteScore: 7.8

自引率: 8.7%

年发文量: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Water-promoted regio-selective trifluoromethylation of vinyl conjugated diazoacetates

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