Os(ii/iii) complex supports pH-insensitive electrochemical DNA-based sensing with superior operational stability than the benchmark methylene blue reporter

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发布日期 2023-01-05

DOI 10.1039/D2AN01901A

影响因子 4.616

作者

Miguel Aller Pellitero, Nandini Kundu, Jonathan Sczepanski

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摘要

DNA-based electrochemical sensors use redox reporters to transduce affinity events into electrical currents. Ideally, such reporters must be electrochemically reversible, chemically stable for thousands of redox cycles, and tolerant to changing chemical environments. Here we report the first use of an Os(II/III) complex in DNA-based sensors, which undergoes pH-insensitive electron transfer with 35% better operational stability relative to the benchmark methylene blue, making it a promising reporter for continuous molecular monitoring applications where pH fluctuates with time.

期刊推荐

Chemical Reviews

Canadian Metallurgical Quarterly

Carbon

Australian Journal of Chemistry

Chemistry of Heterocyclic Compounds

Doklady Chemistry

Biopolymers

Chemistry of Natural Compounds

Accounts of Chemical Research

Journal of the Chinese Chemical Society

来源期刊

Analyst

CiteScore: 7.8

自引率: 5.6%

年发文量: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

Os(ii/iii) complex supports pH-insensitive electrochemical DNA-based sensing with superior operational stability than the benchmark methylene blue reporter

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