Enolate addition to bicyclobutanes enables expedient access to 2-oxo-bicyclohexane scaffolds
文献信息
Kyla J. Woelk, Kushal Dhake, Nathan D. Schley, David C. Leitch
We report the synthesis of 2-oxo-bicyclo[2.1.1]hexanes (2-oxo-BCHs) from bicyclobutanes (BCBs) and readily available enolate precursors. Glycine-derived enolates directly give protected 2-oxo-3-amino-BCH derivatives that can be further functionalized. Arylacetate derivatives are also suitable enolate precursors, giving 2-oxo-3-aryl-BCH scaffolds from readily available starting materials.
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