Concurrent Cu(ii)-initiated Fenton-like reaction and glutathione depletion to escalate chemodynamic therapy
文献信息
Ashwini Kumar, Ayushi Chaudhary, Bhumika Agrahari, Kajal Chaudhary, Pooran Kumar, Ritika Gautam Singh
Chemodynamic therapy is an evolving therapeutic strategy but there are certain limitations associated with its treatment. Herein, we present de novo synthesis and mechanistic evaluation of HL1–HL8 ligands and their corresponding CuII(L1)2–CuII(L8)2. The most active Cu(L2)2 (IC50 = 5.3 μM, MCF-7) complex exclusively depletes glutathione while simultaneously promoting ROS production. Cu(L2)2 also affects other macromolecules like the mitochondrial membrane and DNA while activating the unfolded protein response cascade.
期刊推荐

Russian Chemical Bulletin

Chemical Communications

Crystallography Reports

Chemistry Education Research and Practice

Organic Process Research & Development

Current Opinion in Solid State & Materials Science

Journal of Saudi Chemical Society

Russian Journal of Organic Chemistry

Nature Medicine

Journal of Peptide Science
相关文献
DFT studies on quantum mechanical tunneling in tautomerization of three-membered rings
DOI: 10.1039/C8CP03963A
A variationally computed room temperature line list for AsH3
Phillip A. Coles, Sergei N. Yurchenko, Richard P. Kovacich, James Hobby, Jonathan Tennyson
DOI: 10.1039/C8CP07110A
Fine probing the effect of replacing [PF6]− with [PF3(C2F5)3]− on the local structure and nanoscale organization of [bmim]+-based ionic liquids using MD simulation
Soraya Ebrahimi
DOI: 10.1039/C8CP07829G
Conical intersections and intersystem crossings explain product formation in photochemical reactions of aryl azides
Juan Soto, Juan C. Otero, Francisco J. Avila, Daniel Peláez
DOI: 10.1039/C8CP06974C
Ice-binding site of surface-bound type III antifreeze protein partially decoupled from water
Dominique Verreault, Sarah Alamdari, Steven J. Roeters, Ravindra Pandey, Jim Pfaendtner
DOI: 10.1039/C8CP03382J
Discovery of conical intersection mediated photochemistry with growing string methods
Cody Aldaz, Joshua A. Kammeraad, Paul M. Zimmerman
DOI: 10.1039/C8CP04703K
Quantifying the protein–protein association rate in polymer solutions: crowding-induced diffusion and energy modifications
Jing Qing, Anpu Chen, Nanrong Zhao
DOI: 10.1039/C8CP05203D
Structural characterization of nucleotide 5′-triphosphates by infrared ion spectroscopy and theoretical studies
Rianne E. van Outersterp, Jonathan Martens, Giel Berden, Jeffrey D. Steill, Anouk M. Rijs
DOI: 10.1039/C8CP03314E
Intermediate states approach for adsorption studies in flexible metal–organic frameworks
Justyna Rogacka, Filip Formalik, Azahara L. Triguero, Lucyna Firlej, Sofia Calero
DOI: 10.1039/C8CP06817H
您可能还喜欢
2-(甲基磺酰基)嘧啶-5-胺(CAS号:56621-92-2)适用哪些法规指南?
该化合物适用的法规指南包括GHS(全球化学品统一分类和标签制度)分类为特定目标器官毒性-单次接触类别3;根据欧盟REACH法规,该化合物需要进行注册和评估;在美...
在合成中是否有4-(4-氯苯基)-1H-咪唑(CAS号:35512-29-9)的替代品?
在合成中,可以考虑使用一些类似的化合物作为4-(4-氯苯基)-1H-咪唑的替代品,如4-(4-溴苯基)-1H-咪唑或4-(4-甲氧基苯基)-1H-咪唑。这些化合...
什么是N~2~-甲基丙氨酸酰胺(CAS号:32012-16-1)?
N~2~-甲基丙氨酸酰胺是一种有机化合物,其化学名为2-(Methylamino)propanamide。它是一种酰胺类化合物,分子式为C4H10N2O,相对分...
如何处理含有N-苄基-3-氨基氧杂环丁烷草酸盐(CAS号:1956341-96-0)的废料?
处理含有N-苄基-3-氨基氧杂环丁烷草酸盐(CAS号:1956341-96-0)的废料时,应首先确保遵循相关法规要求,如GHS和REACH等。通常,废液应先进行...
4-bromo-2-chloro-6-methylbenzoic acid(CAS号:877149-07-0)的物理化学性质是什么?
4-溴-2-氯-6-甲基苯甲酸是一种固体化合物,具有较高的熔点和较低的沸点。它的分子量为261.03 g/mol。该化合物在水中几乎不溶,在有机溶剂中溶解度适中...
2-[(2,5-二氯-4-嘧啶)氨基]-N-甲基苯甲酰胺(CAS号:761440-08-8)通常如何合成?
该化合物通常通过缩合反应合成,典型的方法是将2,5-二氯嘧啶与N-甲基苯甲酰胺在碱性条件下进行偶联反应。常用的碱包括NaH、LDA等强碱。该合成路线具有较高的选...
在合成中是否有3,5-二溴-4-甲基苯胺(CAS号:13194-73-5)的替代品?
3,5-二溴-4-甲基苯胺在某些合成路线中可能没有直接替代品。然而,在某些应用场景下,可以考虑使用其他类似结构的化合物如3,5-二溴-4-硝基苯胺或3,5-二碘...
2-氯喹啉-4-羧酸甲酯(CAS号:62482-26-2)的主要用途是什么?
2-氯喹啉-4-羧酸甲酯主要用于有机合成和药物合成领域,作为中间体或原料。它在合成某些药物和染料时具有重要作用。此外,该化合物还可能用于某些特定的化学研究中。
i>]吡啶(CAS号:474708-88-8)安全吗?
6-溴-8-氯咪唑[1,2-a]吡啶在操作过程中需要谨慎以确保安全。该化合物具有一定的毒性,吸入其蒸气或粉尘可能导致呼吸道刺激。处理时应佩戴适当的防护装备,如手...
来源期刊
Chemical Communications

ChemComm publishes urgent research which is of outstanding significance and interest to experts in the field, while also appealing to the journal’s broad chemistry readership. Our communication format is ideally suited to short, urgent studies that are of such importance that they require accelerated publication. Our scope covers all topics in chemistry, and research at the interface of chemistry and other disciplines (such as materials science, nanoscience, physics, engineering and biology) where there is a significant novelty in the chemistry aspects. Major topic areas covered include: Analytical Chemistry Catalysis Chemical Biology and medicinal chemistry Computational Chemistry and Machine Learning Energy and sustainable chemistry Environmental Chemistry Green Chemistry Inorganic Chemistry Materials Chemistry Nanoscience Organic Chemistry Physical Chemistry Polymer Chemistry Supramolecular Chemistry
![trans,trans-4-n-Propyl-4-[4-(trifluoromethoxy)phenyl]bicyclohexyl structure trans,trans-4-n-Propyl-4-[4-(trifluoromethoxy)phenyl]bicyclohexyl structure](https://cnstatic.chemtradehub.com/structs/133/133937-72-1-25ef.webp)
![5-Methoxy-1H-pyrrolo[3,2-b]pyridine structure 5-Methoxy-1H-pyrrolo[3,2-b]pyridine structure](https://cnstatic.chemtradehub.com/structs/172/17288-40-3-a8d1.webp)
![5-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)-2H-pyrazolo[3,4-c]pyridazin-3-amine structure 5-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)-2H-pyrazolo[3,4-c]pyridazin-3-amine structure](https://cnstatic.chemtradehub.com/structs/865/865362-74-9-0091.webp)

![(3R)-3-(3-Fluorophenyl)-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)propanoic acid structure (3R)-3-(3-Fluorophenyl)-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)propanoic acid structure](https://cnstatic.chemtradehub.com/structs/500/500789-04-8-20dd.webp)