PhNCO-enabled synthesis of secondary amides from N-(2-aminophenyl)benzamides

文献信息

发布日期 2023-12-06

DOI 10.1039/D3NJ04995G

影响因子 3.591

作者

Karthick Govindan, Nian-Qi Chen, Alageswaran Jayaram

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摘要

We have successfully developed an efficient method for synthesizing secondary amides utilizing easily accessible N-(2-aminophenyl)benzamide and phenyl isocyanate. Notably, the leaving group can be easily recuperated as a carbonylated N-heterocycle, which holds notable relevance in pharmaceutical applications. The crux of this strategy involves a sequential nucleophilic/intramolecular addition process of phenyl isocyanate, followed by transamidation. Moreover, the protocol features atom-economy, practicality, a one-pot two-step reaction, and facile preparation of substrates.

期刊推荐

Pharmacological Reviews

Journal of Organometallic Chemistry

Pure and Applied Chemistry

Proceedings of the National Academy of Sciences of the United States of America

Journal of Medicinal Chemistry

Science

Journal of Physics and Chemistry of Solids

Organic Preparations and Procedures International

Kinetics and Catalysis

Science Progress

来源期刊

New Journal of Chemistry

CiteScore: 5.3

自引率: 3.7%

年发文量: 2153

NJC (New Journal of Chemistry) is a broad-based primary journal encompassing all branches of chemistry and its sub-disciplines. It contains full research articles, communications, perspectives and focus articles. This well-established journal, owned by the Centre National de la Recherche Scientifique (CNRS) of France, has been co-published with the Royal Society of Chemistry since January 1998. NJC is the forum for the publication of high-quality, original and significant work that opens new directions in chemistry or other scientific disciplines. In addition to having a significant chemical component, work published in NJC must demonstrate that it will have an impact on areas of research other than that of the reported work.

PhNCO-enabled synthesis of secondary amides from N-(2-aminophenyl)benzamides

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