Synthesis of functionalized tetrahydrodibenzo[b,g][1,8]naphthyridin-1(2H)-ones through base-promoted annulation of quinoline-derived dipolarophiles and cyclic enaminones

文献信息

发布日期 2023-11-16

DOI 10.1039/D3OB01547E

影响因子 3.876

作者

Wenjun Luo, Xinghua Zheng, Fanglian Zhang, Qiuya Luo, Wen-Ting Deng, Lipeng Long, Daohong Yu, Zhong-Xia Wang, Zhengwang Chen

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摘要

An eco-friendly and metal-free method for the synthesis of tetrahydrodibenzo[b,g][1,8]naphthyridin-1(2H)-ones was established. Quinoline-derived dipolarophiles and cyclic enaminones as starting materials undergo a 1,4-Michael addition/SNAr tandem annulation reaction affording the target products. This approach features transition metal-free conditions, good functional group tolerance and operational simplicity.

期刊推荐

Advanced Engineering Materials

Photochemical & Photobiological Sciences

Angewandte Chemie International Edition

Green Chemistry

Lab on a Chip

Journal of Enzyme inhibition and Medicinal Chemistry

Molecules

Environmental Toxicology and Pharmacology

Mini-Reviews in Medicinal Chemistry

Current Pharmaceutical Biotechnology

来源期刊

Organic & Biomolecular Chemistry

CiteScore: 3.4

自引率: 10.3%

年发文量: 1041

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.

Synthesis of functionalized tetrahydrodibenzo[b,g][1,8]naphthyridin-1(2H)-ones through base-promoted annulation of quinoline-derived dipolarophiles and cyclic enaminones

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来源期刊

Organic & Biomolecular Chemistry

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