Raman structural study of thymine and its 2′-deoxy-ribosyl derivatives in solid state, aqueous solution and when adsorbed on silver nanoparticles

文献信息

发布日期 2002-04-16
DOI 10.1039/B110564G
影响因子 3.676
作者

Laura Rivas, Santiago Sánchez-Cortés, José V. García-Ramos


查看原文

摘要

The structures of thymine, 2′-deoxythymidine (dT), 5′-thymidinemonophosphate (TMP) and the anti-HIV drug 3′-azido-3′-deoxythymidine (AZT) are studied in this work in solid state, aqueous solution and when these molecules are adsorbed on Ag colloids by means of Raman and surface-enhanced Raman spectroscopy (SERS). The presence of a ribosyl group in the thymine N(1) position induces a change in the electrodynamical properties of the corresponding nucleosides and nucleotides of this base resulting in a different adsorption on the metal. In addition, the presence of substituents such as phosphate in TMP and azido group in AZT influences significantly the conformation of these molecules in solid state, in aqueous solution and adsorbed on the metal surface, as well as the orientation that they adopt on the metal. The molecular conformation of these thymine derivatives has an important significance because of the relationship existing between structure and biological activity.

相关文献

Synthesis of 2,3-diaza-anthraquinones via the bidentate Lewis acid catalysed inverse electron-demand Diels–Alder (IEDDA) reaction

Longcheng Hong, Sebastian Ahles, Marcel A. Strauss, Christian Logemann, Hermann A. Wegner

2017-04-05 Research Article

DOI: 10.1039/C7QO00172J

Mechanistic insights into intermolecular cyclization of ring-fused benzocyclobutenols with alkynes catalyzed by [{Ir(OMe)COD}2]

Yang Zhao, Ping Wang, Yun Gao, Chen Zhu, Wei Liu, Yong Wang

2019-02-04 Research Article

DOI: 10.1039/C8QO01371C

An efficient synthesis of fluoro-neplanocin A analogs using electrophilic fluorination and palladium-catalyzed dehydrosilylation

Dnyandev B. Jarhad, Min Hwan Jang, Young Sup Shin, Hong-Rae Kim, Young Eum Hyun, Ji-seong Yoon, Lak Shin Jeong

2019-02-12 Research Article

DOI: 10.1039/C9QO00099B

Methodology and applications of the hexadehydro-Diels–Alder (HDDA) reaction

Todd B. Marder

2017-03-20 Review Article

DOI: 10.1039/C7QO00071E

Synthesis of a figure-eight azahelicene dimer with high emission and CPL properties

Ayako Ushiyama, Satoru Hiroto, Junpei Yuasa, Tsuyoshi Kawai, Hiroshi Shinokubo

2016-11-01 Research Article

DOI: 10.1039/C6QO00629A

An efficient approach to generate aryl carbenes: gold-catalyzed sequential activation of 1,6-diynes

Tongxiang Cao, Kai Chen

2016-12-21 Research Article

DOI: 10.1039/C6QO00769D

Electronic and steric effects on the three-fold Scholl-type cycloheptatriene ring formation around a tribenzotriquinacene core‡

Ho-Wang Ip, Hak-Fun Chow, Dietmar Kuck

2017-03-16 Research Article

DOI: 10.1039/C7QO00132K

The direct decarboxylative allylation of N-arylglycine derivatives by photoredox catalysis

Yingqian Duan, Muliang Zhang, Rehanguli Ruzi, Zhongkai Wu

2016-12-26 Research Article

DOI: 10.1039/C6QO00711B

Efficient synthesis of multisubstituted 2-alkenylpyridines via 2,3-rearrangement of O-homoallenylic oximes

Itaru Nakamura, Yoshiharu Oyama, Dong Zhang

2017-02-09 Research Article

DOI: 10.1039/C6QO00703A

您可能还喜欢

化合物问答

如何储存8-溴-4-羟基-6-(三氟甲氧基)喹啉-3-羧酸乙酯(CAS号:1072944-81-0)?

8-溴-4-羟基-6-(三氟甲氧基)喹啉-3-羧酸乙酯应储存在阴凉、干燥的地方,避免光照和高温。建议使用密封容器进行储存,以防止水分和空气的影响。

1072944-81-0Ethyl 8-bromo-4-hydr...
化合物问答

2,2-二(2-呋喃基)丙烷(CAS号:17920-88-6)的市场或研究趋势如何?

2,2-二(2-呋喃基)丙烷的研究趋势主要集中在新型材料的开发和应用,如高分子材料、有机光电材料等。市场趋势方面,随着环保要求的提高和新材料的应用,该化合物的需...

17920-88-62,2'-(2,2-Propanediy...
化合物问答

如何处理含有螺[呋喃并[3,4-b]吡啶-5(7H),4'-哌啶]-7-酮盐酸盐(CAS号:475152-31-9)的废料?

对于含有螺[呋喃并[3,4-b]吡啶-5(7H),4'-哌啶]-7-酮盐酸盐的废料,应首先进行分类和分离,以减少危险物质的数量。随后,可以考虑通过化学氧化、生物...

475152-31-97H-Spiro[furo[3,4-b]...
化合物问答

Cinnamyl 3-aminobut-2-enoate(CAS号:113898-97-8)安全吗?

Cinnamyl 3-氨基丁-2-烯酸在接触皮肤和眼睛时可能会引起刺激。应避免吸入其粉尘和烟雾。操作时应穿戴适当的个人防护装备,如手套、护目镜和实验室外套。

113898-97-8Cinnamyl 3-aminobut-...
化合物问答

反式-2-十二碳烯二酸(CAS号:6402-36-4)的市场或研究趋势如何?

反式-2-十二碳烯二酸在医药、材料科学等领域有一定的应用,但其市场相对较小。近年来,由于环保意识的提升,对环境友好型化学品的需求增加,研究倾向于开发更绿色的合成...

6402-36-4Traumatic Acid
化合物问答

什么是(9ci)-1H-苯并咪唑-5-乙酸(CAS号:473895-86-2)?

(9ci)-1H-苯并咪唑-5-乙酸是一种含氮杂环化合物,其化学结构为1H-苯并咪唑-5-乙酸。该化合物具有特定的分子式C8H7NO2,属于有机酸类化合物。

473895-86-21H-Benzimidazol-5-yl...
化合物问答

酞菁蓝(CAS号:147-14-8)的主要用途是什么?

酞菁蓝主要用作颜料和染料,广泛应用于塑料、油墨、涂料、纺织品及橡胶工业中。它也用于光敏材料,如太阳能电池和光刻胶。在医疗领域,酞菁蓝因其光敏特性被用于某些光动力...

147-14-8Copper(2+) phthalocy...
化合物问答

5-甲基-1,2,3,4-四氢异喹啉(CAS号:123593-99-7)安全吗?

5-甲基-1,2,3,4-四氢异喹啉在使用和储存时需要谨慎处理。它具有一定的毒性,应避免吸入其蒸气或直接接触皮肤和眼睛。操作此化合物时,建议佩戴防护眼镜、实验服...

123593-99-75-Methyl-1,2,3,4-tet...
化合物问答

如何处理含有3',4',5'-三甲氧基苯乙酮(CAS号:1136-86-3)的废料?

含有3',4',5'-三甲氧基苯乙酮的废液应首先确保其是否为危险废物,根据当地法规确定处理方法。通常,这类有机废液可以采用中和反应降低其pH值,然后通过蒸馏或萃...

1136-86-31-(3,4,5-Trimethoxyp...
化合物问答

如何储存KI-7(CAS号:1489263-00-4)?

KI-7应储存在通风良好的干燥环境中,避免光照和高温。建议使用密封容器储存,并保持在阴凉处。储存温度应控制在室温范围内,一般建议不超过25°C。避免与氧化剂接触...

1489263-00-42-(1-Benzyl-1H-indol...

来源期刊

Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics
CiteScore: 5.5
自引率: 10.3%
年发文量: 3036

Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.

推荐供应商

免责声明
本页面提供的学术期刊信息仅供参考和研究使用。我们与任何期刊出版商均无关联,也不处理投稿事宜。如有投稿相关咨询,请直接联系相关期刊出版商。
如发现页面信息有误,请发送邮件至 support@chemtradehub.com 联系我们。我们将及时核实并处理您的问题。