Single molecule studies of DNA binding proteins using optical tweezers

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发布日期 2006-06-30

DOI 10.1039/B600157M

影响因子 4.616

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摘要

Optical tweezers have become a versatile tool in the biological sciences. Combined with various types of optical microscopy, they are being successfully used to discover the fundamental mechanism of biological processes. Recently, the study of proteins acting on DNA was aggressively undertaken at the single-molecule level. Here, we review the most recent studies which have revealed the dynamic behavior of individual protein molecules at work on DNA, providing detailed mechanistic insight that could not be revealed, at least not easily, using bulk-phase or ensemble approaches.

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Acta Metallurgica Sinica-English Letters

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Critical Reviews in Solid State and Materials Sciences

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Journal of the Indian Institute of Science

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Analyst

CiteScore: 7.8

自引率: 5.6%

年发文量: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

Single molecule studies of DNA binding proteins using optical tweezers

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