A near-infrared fluorescent probe for lipid hydroperoxides in living cells
文献信息
Ping Li, Bo Tang, Yanlong Xing, Puming Li, Guiwen Yang, Liang Zhang
An NIR (near-infrared) fluorescent probe TCP (tricarbocyanine diphenylphosphine) including a non-conjugated ‘pre-tricarbocyanine’ was designed and synthesized for visualizing lipid hydroperoxides (ROOH) in living cells. The excitation and emission spectra of tricarbocyanine in the NIR region can effectively avoid background fluorescence interference in biological systems. The probe exhibited a rapid fluorescence response to ROOH and high selectivity for ROOH over other ROS (reactive oxygen species) and some biological compounds, and the limit of detection was 38 pM. In addition, the probe was stable, and less cytotoxic, which indicated that it has potential application in detecting lipid hydroperoxides in living biological systems.
期刊推荐

Journal of Physics and Chemistry of Solids

Russian Chemical Reviews

Journal of Organometallic Chemistry

Helvetica Chimica Acta

Organic Preparations and Procedures International

Proceedings of the National Academy of Sciences of the United States of America

Nature

European Journal of Wood and Wood Products

Molecular Pharmacology

Journal of Heterocyclic Chemistry
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