Bactericidal mechanism of nanopatterned surfaces

文献信息

发布日期 2015-12-01

DOI 10.1039/C5CP05646B

影响因子 3.676

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摘要

The quest to design and fabricate new antibacterial surfaces is an important task to meet the urgent demands of biomedical applications. Recently, a mechanical mechanism for killing adherent bacteria was discovered on nanopatterned surfaces, but there is a lack of understanding of the bactericidal mechanism. Here we present a quantitative thermodynamic model to study the bactericidal mechanism of nanopatterned surfaces through analyzing the total free energy change of bacterial cells. By comparing the bacterial cells on a flat surface and nanopatterned surface, our theoretical results reveal that cicada wing-like nanopatterned surfaces have more effective bactericidal properties than flat surfaces because a patterned surface leads to a drastic increase of the contact adhesion area. Our model also reveals some details of the influence mechanism, and gives some important information about how to improve the bactericidal properties through designing the morphology of the patterned surface.

期刊推荐

NDT & E International

Heteroatom Chemistry

Bioorganic & Medicinal Chemistry Letters

Electroanalysis

Medicinal Chemistry Research

Journal of Asian Natural Products Research

Critical Reviews in Solid State and Materials Sciences

Atomization and Sprays

Journal of Chemical Sciences

Journal of the Indian Institute of Science

来源期刊

Physical Chemistry Chemical Physics

CiteScore: 5.5

自引率: 10.3%

年发文量: 3036

Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.

Bactericidal mechanism of nanopatterned surfaces

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