Small molecule detection by lateral flow strips via aptamer-gated silica nanoprobes

文献信息

发布日期 2016-03-18

DOI 10.1039/C6AN00273K

影响因子 4.616

作者

V. Cengiz Özalp, Dilek Çam, Frank J. Hernandez, Luiza I. Hernandez, Thomas Schäfer

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摘要

A fast, sensitive and ratiometric biosensor strategy for small molecule detection was developed through nanopore actuation. The new platform engineers together, a highly selective molecular recognition element, aptamers, and a novel signal amplification mechanism, gated nanopores. As a proof of concept, aptamer gated silica nanoparticles have been successfully used as a sensing platform for the detection of ATP concentrations at a wide linear range from 100 μM up to 2 mM.

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Analyst

CiteScore: 7.8

自引率: 5.6%

年发文量: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

Small molecule detection by lateral flow strips via aptamer-gated silica nanoprobes

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