Mild and efficient synthesis of ω,ω-heterodifunctionalized polymers and polymer bioconjugates

文献信息

发布日期 2017-03-13

DOI 10.1039/C7PY00225D

影响因子 5.582

作者

C. Adrian Figg, Ashton N. Bartley, Tomohiro Kubo, Bryan S. Tucker, Ronald K. Castellano, Brent S. Sumerlin

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摘要

This report describes the efficient preparation of ω,ω-heterodifunctionalized polymers and polymer bioconjugates under mild conditions using a recently introduced reagent, benzotrifuranone (BTF). Demonstrated is how BTF enables introduction of differentially “clickable” functional groups (e.g., alkenes and alkynes) to monomethyl ether poly(ethylene glycol) amine at ambient temperature using near-stoichiometric amounts of reagents, in contrast to conventional polymer heterofunctionalization approaches that may require high temperatures, significant excesses of reagents, and/or numerous synthetic steps. Showcasing the methodology is facile access to an ω,ω-heterodifunctional polymer bearing a fluorescent (coumarin) dye and biotin. Found, in addition to avidin binding by the polymer bioconjugate, is the unexpected disruption of avidin tetramer formation.

期刊推荐

Herald of the Russian Academy of Sciences

Topics in Catalysis

Bioorganic & Medicinal Chemistry

Journal of Chemical Sciences

Heteroatom Chemistry

Biocatalysis and Biotransformation

Atomization and Sprays

Bioorganic & Medicinal Chemistry Letters

NDT & E International

Medicinal Chemistry Research

来源期刊

Polymer Chemistry

CiteScore: 8.6

自引率: 7.3%

年发文量: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Mild and efficient synthesis of ω,ω-heterodifunctionalized polymers and polymer bioconjugates

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来源期刊

Polymer Chemistry

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