A modular approach to highly functionalized 3-sulfonylfurans via conjugate addition of 3-cyclopropylideneprop-2-en-1-ones with sodium sulfinates and sequential 5-endo-trig iodocyclization

文献信息

发布日期 2017-06-14
DOI 10.1039/C7QO00362E
影响因子 5.281
作者

Maozhong Miao, Huaping Xu, Yi Luo, Mengchao Jin, Zhengkai Chen, Jianfeng Xu, Hongjun Ren


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摘要

A highly efficient conjugate addition and 5-endo-trig cyclization reaction of 3-cyclopropylideneprop-2-en-1-ones with sodium sulfinates in the presence of iodine is described. A wide variety of densely functionalized 3-sulfonylfurans are furnished by single-step and one-pot methods, respectively. The results of such postcyclization modifications are also presented.

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Organic Chemistry Frontiers

Organic Chemistry Frontiers
CiteScore: 7.8
自引率: 8.7%
年发文量: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

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