Synthesis of a non-natural glucose-2-phosphate ester able to dupe the acc system of Agrobacterium fabrum
文献信息
Si-Zhe Li, Armelle Vigouroux, Mohammed Ahmar, Abbas El Sahili, Laurent Soulère, Laïla Sago, David Cornu, Solange Moréra, Yves Queneau
The first non-natural derivative of the rare D-glucose-2-phosphate (G2P), namely glucose-2-(O-lactic acid phosphate) (G2LP), has been synthesized. When used as sole carbon source, G2LP enables bacterial growth of the plant pathogenic strain Agrobacterium fabrum C58 (formerly referred to as Agrobacterium tumefaciens). X-ray crystallography and affinity measurements investigations reveal that G2LP binds the periplasmic binding protein (PBP) AccA similarly to the natural compounds and with the same affinity. Moreover, enzymatic assays show that it is able to serve as substrate of the phosphodiesterase AccF. The properties found for G2LP demonstrate that the very unusual glucose-2-phosphoryl residue, present in G2LP, can be used as structural feature for designing non-natural systems fully compatible with the Acc cascade of A. fabrum.
期刊推荐
相关文献
Light induced oxidation of an indoline derived system triggered spherical aggregates
DOI: 10.1039/C7CP04988A
Investigation of the dynamics of aqueous proline solutions using neutron scattering and molecular dynamics simulations
Paula Malo de Molina, Bernhard Frick, Andrew Wildes, Arantxa Arbe
DOI: 10.1039/C7CP05474B
The duality of UiO-67-Pt MOFs: connecting treatment conditions and encapsulated Pt species by operando XAS
E. Borfecchia, A. Martini, A. V. Soldatov, S. Øien-Ødegaard, B. T. Lønstad-Bleken, U. Olsbye, K. P. Lillerud, M. Manzoli
DOI: 10.1039/C7CP05185A
Confined water dynamics in a hydrated photosynthetic pigment–protein complex
Yael Kurzweil-Segev, Ido Eisenberg, Shira Yochelis, Nir Keren, Yossi Paltiel, Yuri Feldman
DOI: 10.1039/C7CP05417C
A novel explanation for the increased conductivity in annealed Al-doped ZnO: an insight into migration of aluminum and displacement of zinc
A. Momot, M. N. Amini, G. Reekmans, D. Lamoen, B. Partoens, D. R. Slocombe, K. Elen, P. Adriaensens, A. Hardy, M. K. Van Bael
DOI: 10.1039/C7CP02936E
Attractive PH⋯HP interactions revealed by state-of-the-art ab initio calculations
Sirous Yourdkhani, Mirosław Jabłoński, Jorge Echeverría
DOI: 10.1039/C7CP04412G
Isomerization of methoxy radical in the troposphere: competition between acidic, neutral and basic catalysts
Saptarshi Sarkar, Subhasish Mallick, Deepak, Pradeep Kumar, Biman Bandyopadhyay
DOI: 10.1039/C7CP05475K
Substitution pattern on anthrol carbaldehydes: excited state intramolecular proton transfer (ESIPT) with a lack of phototautomer fluorescence
S. Chaiwongwattana, Đ. Škalamera, N. Došlić, C. Bohne, N. Basarić
DOI: 10.1039/C7CP05472F
Giant anisotropic photogalvanic effect in a flexible AsSb monolayer with ultrahigh carrier mobility
Pei Zhao, Jianwei Li, Wei Wei, Qilong Sun, Hao Jin, Baibiao Huang, Ying Dai
DOI: 10.1039/C7CP05201D
您可能还喜欢
如何处理含有8-氯咪唑并[1,2-A]吡嗪(CAS号:69214-33-1)的废料?
处理含有8-氯咪唑并[1,2-A]吡嗪的废料时,应首先将其收集并进行化学回收或降解。如果无法回收,需采用安全的化学处理方法,如中和、氧化还原或沉淀。处理过程中需...
Calhex 231 hydrochloride(CAS号:2387505-78-2)适用哪些法规指南?
Calhex 231 hydrochloride 需要遵循《全球化学品统一分类和标签制度》(GHS)的分类和标签要求,以及欧盟的《化学品注册、评估、授权和限制条...
11-Beta,17-alpha,21-三羟基-5-beta-孕烯-3,20-二酮(CAS号:1482-50-4)的物理化学性质是什么?
11-Beta,17-alpha,21-三羟基-5-beta-孕烯-3,20-二酮是一种无色结晶性粉末,分子量为372.45 g/mol。该化合物在水中的溶解度...
处理5-异丙基-1,3,4-恶二唑-2-羧酸(CAS号:944907-13-5)时应注意哪些实验室安全事项?
处理5-异丙基-1,3,4-恶二唑-2-羧酸时应注意以下安全事项:穿戴适当的个人防护装备,包括实验室外套、手套和护目镜;操作应在通风橱中进行,以减少吸入或接触有...
benzyl 3-bromopropanoate(CAS号:90841-55-7)安全吗?
Benzyl 3-bromopropanoate属于有毒物质,吸入、摄入或皮肤接触均可能对人体造成伤害。操作时应佩戴防护眼镜、口罩和手套,避免吸入蒸汽和直接接触...
什么是(R)-N-苄氧羰基-3,4-二氢-1H-异喹啉羧酸(CAS号:151004-88-5)?
(R)-N-苄氧羰基-3,4-二氢-1H-异喹啉羧酸是一种含有苄氧羰基和异喹啉环结构的化合物,分子式为C17H15NO3。它是一种有机化合物,具有一定的生物活性...
在合成中是否有1-苄基吡啶嗡-3-羧酸盐(CAS号:15990-43-9)的替代品?
可以考虑使用1-苄基吡啶-3-羧酸盐作为1-苄基吡啶嗡-3-羧酸盐的替代品。此外,还可以探索其他类似物,如1-苄基吡啶-3-氨基甲酸酯等。具体的替代品选择需根据...
(2,6-二甲基吡啶-3-基)甲醇(CAS号:582303-10-4)安全吗?
(2,6-二甲基吡啶-3-基)甲醇在使用时需注意安全,应避免吸入其蒸汽,接触皮肤和眼睛。操作应在通风良好的环境中进行,佩戴适当的个人防护装备。
5-溴-2-乙烯基吡啶(CAS号:226883-52-9)的物理化学性质是什么?
5-溴-2-乙烯基吡啶是一种有机化合物,外观为白色固体,具有良好的结晶性。分子量约为190.03 g/mol。它的溶解性在水中较差,但在有机溶剂如二氯甲烷、甲醇...
2-羟基-3-硝基-5-甲基吡啶(CAS号:7464-14-4)应用于哪些行业?
2-羟基-3-硝基-5-甲基吡啶主要应用于医药、聚合物和半导体行业。在医药领域,它可以用作合成其他药物的中间体。在聚合物领域,它可以作为功能性单体参与聚合反应,...
来源期刊
Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.











![N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-beta-phenyl-L-phenylalanine structure N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-beta-phenyl-L-phenylalanine structure](https://cnstatic.chemtradehub.com/structs/201/201484-50-6-c2fc.webp)


