Aryne triggered dearomatization reaction of isoquinolines and quinolines with chloroform‡
文献信息
Jiajing Tan, Binbin Liu, Shuaisong Su
The direct dearomatization reaction of isoquinolines and quinolines with chloroform has been accomplished through in situ electrophilic aryne activation and nucleophile formation. This transition metal-free protocol shows a broad scope of substrates, providing consistently high yields of medicinally-important dihydro(iso)quinoline derivatives. The utility of this method has been further demonstrated in the synthesis of deuterated analogues.
期刊推荐

Proceedings of the National Academy of Sciences of the United States of America

European Journal of Wood and Wood Products

Journal of Catalysis

Pharmacological Reviews

Journal of Physics and Chemistry of Solids

Helvetica Chimica Acta

Journal of Medicinal Chemistry

Fibre Chemistry

Journal of Heterocyclic Chemistry

Science Progress
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Organic Chemistry Frontiers

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry




