Synthesis of functionalized diarylbenzofurans via Ru-catalyzed C–H activation and cyclization under air: rapid access to the polycyclic scaffold of diptoindonesin G
文献信息
发布日期
2021-11-04
DOI
10.1039/D1QO01242H
影响因子
5.281
作者
Lufeng Ouyang, Zhigeng Lin, Shiqi Li, Baoyin Chen, Jidan Liu, Wen-Jing Shi, Liyao Zheng
查看原文
摘要
An efficient method was developed for synthesis of 2,3-diarylbenzofuran-4-carboxylic acids from m-hydroxybenzoic acids and alkynes via Ru-catalyzed C–H alkenylation and aerobic annulation, in which air was employed as a mild oxidant. This method is compatible for various substrates with high regioselectivity for the C–H bonds. The obtained products can be transformed to polycyclic compounds via intramolecular Friedel–Crafts acylation. This protocol was successfully applied for total synthesis of diptoindonesin G, a natural product with a benzofuran-containing tetracyclic scaffold and potent biological activities.
期刊推荐
Polycyclic Aromatic Compounds
Journal of Chemical Sciences
Acta Metallurgica Sinica-English Letters
Biocatalysis and Biotransformation
Medicinal Chemistry Research
Critical Reviews in Solid State and Materials Sciences
Electroanalysis
Herald of the Russian Academy of Sciences
Chinese Journal of Chemistry
Bioorganic & Medicinal Chemistry
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来源期刊
Organic Chemistry Frontiers
CiteScore:
7.8
自引率:
8.7%
年发文量:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
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