Metal-free electrochemical synthesis of α-ketoamides via decarboxylative coupling of α-keto acids with isocyanides and water

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发布日期 2021-10-26

DOI 10.1039/D1QO01351C

影响因子 5.281

作者

Feng Zhao, Na Meng, Ting Sun, Jiangwei Wen, Xiaohui Zhao

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摘要

A mild and environmentally benign electrochemical strategy has been developed for the synthesis of α-ketoamides via a decarboxylative coupling reaction of α-keto acids with isocyanides and water. The present reaction was efficiently conducted under constant current electrolysis using n-Bu4NI as the electrolyte in an undivided cell. A series of α-ketoamides could be conveniently and rapidly constructed at room temperature in the absence of transition metal catalysts and external oxidants. Mechanistic studies suggested that water not only served as a starting material to construct α-ketoamides, but also played an important role in promoting the electrochemical redox of α-keto acids.

期刊推荐

Proceedings of the National Academy of Sciences of the United States of America

Pure and Applied Chemistry

Organic Preparations and Procedures International

Journal of Medicinal Chemistry

Israel Journal of Chemistry

Pharmacological Reviews

Fibre Chemistry

Nature

Molecular Pharmacology

European Journal of Wood and Wood Products

来源期刊

Organic Chemistry Frontiers

CiteScore: 7.8

自引率: 8.7%

年发文量: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Metal-free electrochemical synthesis of α-ketoamides via decarboxylative coupling of α-keto acids with isocyanides and water

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