A DNA rotary nanodevice operated by enzyme-initiated strand resetting

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发布日期 2023-12-01

DOI 10.1039/D3CC05487J

影响因子 6.222

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摘要

DNA nanostructures that respond to external stimuli have found applications in several areas such as biosensing, drug delivery and molecular computation. The use of different types of stimuli in a single operation provides another layer of control for the reconfiguration of nucleic acid nanostructures. This work demonstrates the use of a ribonuclease to “unset” a nucleic acid nanodevice based on the paranemic crossover (PX) DNA and specific DNA inputs to “reset” the structure into a juxtaposed DNA (JX2) configuration, resulting in a 180° rotation of the helical domains. Such operations would be useful in translational applications where DNA nanostructures can be designed to reconfigure on the basis of more than one stimulus.

期刊推荐

Organic Preparations and Procedures International

Helvetica Chimica Acta

Journal of Medicinal Chemistry

Journal of Physics and Chemistry of Solids

European Journal of Wood and Wood Products

Fibre Chemistry

Journal of Heterocyclic Chemistry

Journal of Organometallic Chemistry

Pharmacological Reviews

Science Progress

来源期刊

Chemical Communications

CiteScore: 8.6

自引率: 4.7%

年发文量: 2458

ChemComm publishes urgent research which is of outstanding significance and interest to experts in the field, while also appealing to the journal’s broad chemistry readership. Our communication format is ideally suited to short, urgent studies that are of such importance that they require accelerated publication. Our scope covers all topics in chemistry, and research at the interface of chemistry and other disciplines (such as materials science, nanoscience, physics, engineering and biology) where there is a significant novelty in the chemistry aspects. Major topic areas covered include: Analytical Chemistry Catalysis Chemical Biology and medicinal chemistry Computational Chemistry and Machine Learning Energy and sustainable chemistry Environmental Chemistry Green Chemistry Inorganic Chemistry Materials Chemistry Nanoscience Organic Chemistry Physical Chemistry Polymer Chemistry Supramolecular Chemistry

A DNA rotary nanodevice operated by enzyme-initiated strand resetting

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