Iridium-catalysed reductive allylic amination of α,β-unsaturated aldehydes

文献信息

发布日期 2023-12-12

DOI 10.1039/D3OB01753B

影响因子 3.876

作者

Liang Liu, Renshi Luo, Jinghui Tong, Jianhua Liao

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摘要

Allylic amination is a powerful tool for constructing N-allylic amines widely found in bioactive molecules. Generally, allylic alcohols and unsaturated hydrocarbons have been considered for allylic amination reactions to minimize waste production. Herein, we present an iridium-catalysed method for reductive allylic amination of α,β-unsaturated aldehydes with amines to afford N-allylic amines under air conditions. This protocol is demonstrated to provide products from many substrates (41 examples) in moderate-to-excellent yields. This synthetic methodology is also highlighted by the synthesis of drug molecules, optically pure products, as well as scale-up experiments.

期刊推荐

Russian Journal of Applied Chemistry

Russian Journal of General Chemistry

Journal of Natural Medicines

Crystallography Reports

Chemical Communications

Russian Journal of Bioorganic Chemistry

Journal of Peptide Science

Current Opinion in Colloid & Interface Science

Current Opinion in Solid State & Materials Science

Acta Materialia

来源期刊

Organic & Biomolecular Chemistry

CiteScore: 3.4

自引率: 10.3%

年发文量: 1041

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.

Iridium-catalysed reductive allylic amination of α,β-unsaturated aldehydes

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来源期刊

Organic & Biomolecular Chemistry

推荐化合物

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