Photoinduced cerium-catalyzed C–H acylation of unactivated alkanes

文献信息

发布日期 2023-11-25

DOI 10.1039/D3SC05162E

影响因子 9.825

作者

Jing Cao, Joshua L. Zhu, Karl A. Scheidt

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摘要

Ketones are ubiquitous motifs in the realm of pharmaceuticals and natural products. Traditional approaches to accessing these species involve the addition of metal reagents to carboxyl compounds under harsh conditions. Herein, we report a cerium-catalyzed acylation of unactivated C(sp3)–H bonds using bench-stable acyl azolium reagents under mild and operationally-friendly conditions. This reaction exhibits excellent generality, accommodating a wide range of feedstock chemicals such as cycloalkanes and acyclic compounds as well as facilitating the late-stage functionalization of pharmaceuticals. We demonstrate further applications of our strategy with a three-component radical relay reaction and an enantioselective N-heterocyclic carbene (NHC) and cerium dual-catalyzed reaction.

期刊推荐

Angewandte Chemie International Edition

European Journal of Organic Chemistry

Molecules

Contact Lens & Anterior Eye

Physical Chemistry Chemical Physics

Coloration Technology

Faraday Discussions

Molecular Diversity

Advanced Engineering Materials

Lab on a Chip

来源期刊

Chemical Science

CiteScore: 14.4

自引率: 3.9%

年发文量: 1413

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Photoinduced cerium-catalyzed C–H acylation of unactivated alkanes

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来源期刊

Chemical Science

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