![2,9-Dichloro-5,12-dihydroquinolino[2,3-b]acridine-7,14-dione structure](https://cnstatic.chemtradehub.com/structs/308/3089-17-6-750b.webp "2,9-Dichloro-5,12-dihydroquinolino[2,3-b]acridine-7,14-dione structure")
Fluorescent PEGylation agent by a thiolactone-based one-pot reaction: a new strategy for theranostic combinations
文献信息
发布日期
2014-08-12
DOI
10.1039/C4PY00995A
影响因子
5.582
作者
Yuan Zhao, Bin Yang, Yaling Zhang, Shiqi Wang, Changkui Fu, Yen Wei, Lei Tao
查看原文
摘要
Theranostic combinations usually contain an imaging, a therapeutic and a cloaking component to simultaneously fulfil diagnostic and therapeutic functions. Using upgraded PEGylation technology, a straightforward one-pot strategy based on thiolactone ring-opening has been developed to facilely synthesize a multifunctional PEGylation agent, fluorescent protein-reactive poly(ethylene glycol) (PEG), which can subsequently react with a model therapeutic protein to form a fluorescent PEGylated protein as a model of sophisticated theranostic combinations.
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来源期刊
Polymer Chemistry
CiteScore:
8.6
自引率:
7.3%
年发文量:
457
Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.
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