CuBr-mediated radical cascade difluoroacetamidation of acrylamides using α,α-difluoro-α-(TMS)-acetamides
文献信息
发布日期
2017-05-08
DOI
10.1039/C7QO00209B
影响因子
5.281
作者
Kai Liu, Lin-Chao Sui, Qiao Jin, Deng-Yuan Li, Pei-Nian Liu
查看原文
摘要
Radical cascade difluoroacetamidation of N-(arylsulfonyl)acrylamides with α,α-difluoro-α-(TMS)-acetamides has been achieved for the first time. This CuBr-mediated transformation is easy to perform, generates high yields and shows a good substrate scope. This cascade reaction proceeds via difluoroacetamidation, aryl migration and desulfonylation. The products can be readily transformed into synthetically useful compounds such as difluorofunctionalized esters and alcohols in excellent yields.
期刊推荐
Critical Reviews in Solid State and Materials Sciences
NDT & E International
Heteroatom Chemistry
Medicinal Chemistry Research
Main Group Chemistry
Herald of the Russian Academy of Sciences
Bioorganic & Medicinal Chemistry Letters
Topics in Catalysis
Acta Metallurgica Sinica-English Letters
Atomization and Sprays
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来源期刊
Organic Chemistry Frontiers
CiteScore:
7.8
自引率:
8.7%
年发文量:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
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