Regioselective ortho-functionalization of bromofluorenecarbaldehydes using TMPMgCl·LiCl

文献信息

发布日期 2018-05-15

DOI 10.1039/C8OB01072B

影响因子 3.876

作者

Dominik Göbel, Nils Clamor, Boris J. Nachtsheim

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摘要

A highly regioselective functionalization of 7-bromofluorene-2-carbaldehydes, potent organic chromophores, in position C3 using a mild ortho-metallation strategy (DoM) with TMPMgCl·LiCl has been developed. This approach allows the preparation of highly functionalized fluorene derivatives by conversion of the in situ generated metalated species with various electrophiles giving a fast access to novel organic phosphorescent dyes.

期刊推荐

Bioorganic & Medicinal Chemistry

Polycyclic Aromatic Compounds

Bioorganic & Medicinal Chemistry Letters

Cellulose

Journal of Asian Natural Products Research

Heteroatom Chemistry

Biocatalysis and Biotransformation

Atomization and Sprays

Journal of Chemical Sciences

Herald of the Russian Academy of Sciences

来源期刊

Organic & Biomolecular Chemistry

CiteScore: 3.4

自引率: 10.3%

年发文量: 1041

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.

Regioselective ortho-functionalization of bromofluorenecarbaldehydes using TMPMgCl·LiCl

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来源期刊

Organic & Biomolecular Chemistry

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