A convenient synthetic approach to highly hindered 3,3′-bis(2,4,6-tri-tert-butylphenyl)-BINOL-derived phosphoric acids

文献信息

发布日期 2024-01-04

DOI 10.1039/D3NJ05280J

影响因子 3.591

作者

Zhiqiang Wang, Gen Li

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摘要

Considering the success of BINOL phosphoric acids and a serious lack of preparation methods for hindered chiral phosphoric acid catalysts, herein we present an efficient approach to highly hindered (S) and (R)-3,3′-bis(2,4,6-tri-tert-butylphenyl)-BINOL-derived phosphoric acids with high enantioselectivity. Direct arylations of the C–F bonds in optically pure 3,3′-difluoro-BINOL derivatives with (2,4,6-tri-tert-butylphenyl)magnesium bromide were explored as the key transformation. Optical resolution chromatography was avoided and both enantiomers were successfully prepared on a ten-gram-scale via our method.

期刊推荐

Ceramics International

Heterocycles

Applied Organometallic Chemistry

Journal of the Royal Society of New Zealand

Cellular Polymers

Fire and Materials

Journal of Analytical Atomic Spectrometry

Experimental Techniques

Ferroelectrics Letters Section

Composites Science and Technology

来源期刊

New Journal of Chemistry

CiteScore: 5.3

自引率: 3.7%

年发文量: 2153

NJC (New Journal of Chemistry) is a broad-based primary journal encompassing all branches of chemistry and its sub-disciplines. It contains full research articles, communications, perspectives and focus articles. This well-established journal, owned by the Centre National de la Recherche Scientifique (CNRS) of France, has been co-published with the Royal Society of Chemistry since January 1998. NJC is the forum for the publication of high-quality, original and significant work that opens new directions in chemistry or other scientific disciplines. In addition to having a significant chemical component, work published in NJC must demonstrate that it will have an impact on areas of research other than that of the reported work.

A convenient synthetic approach to highly hindered 3,3′-bis(2,4,6-tri-tert-butylphenyl)-BINOL-derived phosphoric acids

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来源期刊

New Journal of Chemistry

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